A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. All manuscripts are thoroughly refereed through a single-blind peer-review process. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. We look forward to receiving your contributions. Review that discusses recent advances and future perspectives in understanding the role of NAD+during aging.Therapeutic strategies aiming to boost intracellular NAD+levels in the context of age-associated diseases.Cellular and molecular studies presenting novel pathways linking NAD+metabolism to hallmarks of aging.We welcome original research and review articles in which the topics may include (but are not limited to) the following: This Special Issue aims at providing novel insights into the role of NAD+ metabolism in the context of aging and age-associated diseases. In this regard, boosting NAD+ levels by enhancing its biosynthesis or inhibiting its degradation has emerged as a promising therapeutic approach to counteract the aging process and to treat age-associated diseases. The decline in NAD+ levels has been associated with several hallmarks of aging and age-related diseases. These enzymes play a fundamental role in many pivotal cellular processes including DNA repair, regulation of gene expression, redox balance and cell metabolism and signaling. Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme for hundreds of different oxidoreductases as well as an essential cofactor for NAD+-dependent enzymes, such as sirtuins, poly(ADP-ribose) polymerases (PARPs) and NAD+ glycohydrolases (CD38, CD157 and SARM1).